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desvenlafaxine will improve the level or outcome of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, 400 mg) lessen the CYP2D6 substrate dose by up to 50%; no dosage adjustment necessary with desvenlafaxine doses seven consecutive times straight away